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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ICK All Species: 13.64
Human Site: S276 Identified Species: 27.27
UniProt: Q9UPZ9 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UPZ9 NP_055735.1 632 71427 S276 P K K R P T A S Q A L R Y P Y
Chimpanzee Pan troglodytes XP_001154965 633 71532 S277 P K K R P T A S Q A L R Y P Y
Rhesus Macaque Macaca mulatta XP_001100720 616 68399 S260 P K K R P T A S Q A L R Y P Y
Dog Lupus familis XP_538964 685 76968 S329 P K K R P T A S Q A L R Y P Y
Cat Felis silvestris
Mouse Mus musculus Q9JKV2 629 70573 P273 Q W D P K K R P T A S Q A L R
Rat Rattus norvegicus Q62726 629 70550 P273 Q W D P K K R P T A S Q A L R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514373 624 70740 K271 M L H W N P K K R P T A S Q A
Chicken Gallus gallus
Frog Xenopus laevis P23437 297 33852
Zebra Danio Brachydanio rerio NP_956240 633 71283 V277 P K K R P S A V K A L R Y P Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392924 569 65790 G217 F K I C S V I G T P E K D D W
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001200813 576 64528 W224 G T P K K E E W V E G F R L A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P43294 443 50877 M90 L F F I F E C M D H N L Y H I
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 86.8 86.1 N.A. 86.3 85.5 N.A. 56.6 N.A. 23.1 47 N.A. N.A. 45.8 N.A. 48.5
Protein Similarity: 100 99.5 90 89.4 N.A. 92 91.6 N.A. 68.8 N.A. 32.1 60.5 N.A. N.A. 61.3 N.A. 62.1
P-Site Identity: 100 100 100 100 N.A. 6.6 6.6 N.A. 0 N.A. 0 80 N.A. N.A. 6.6 N.A. 0
P-Site Similarity: 100 100 100 100 N.A. 13.3 13.3 N.A. 6.6 N.A. 0 93.3 N.A. N.A. 20 N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. 34.9 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 48.8 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 42 0 0 59 0 9 17 0 17 % A
% Cys: 0 0 0 9 0 0 9 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 17 0 0 0 0 0 9 0 0 0 9 9 0 % D
% Glu: 0 0 0 0 0 17 9 0 0 9 9 0 0 0 0 % E
% Phe: 9 9 9 0 9 0 0 0 0 0 0 9 0 0 0 % F
% Gly: 9 0 0 0 0 0 0 9 0 0 9 0 0 0 0 % G
% His: 0 0 9 0 0 0 0 0 0 9 0 0 0 9 0 % H
% Ile: 0 0 9 9 0 0 9 0 0 0 0 0 0 0 9 % I
% Lys: 0 50 42 9 25 17 9 9 9 0 0 9 0 0 0 % K
% Leu: 9 9 0 0 0 0 0 0 0 0 42 9 0 25 0 % L
% Met: 9 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 9 0 0 0 0 0 9 0 0 0 0 % N
% Pro: 42 0 9 17 42 9 0 17 0 17 0 0 0 42 0 % P
% Gln: 17 0 0 0 0 0 0 0 34 0 0 17 0 9 0 % Q
% Arg: 0 0 0 42 0 0 17 0 9 0 0 42 9 0 17 % R
% Ser: 0 0 0 0 9 9 0 34 0 0 17 0 9 0 0 % S
% Thr: 0 9 0 0 0 34 0 0 25 0 9 0 0 0 0 % T
% Val: 0 0 0 0 0 9 0 9 9 0 0 0 0 0 0 % V
% Trp: 0 17 0 9 0 0 0 9 0 0 0 0 0 0 9 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 50 0 42 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _